Vol. 6, Issue 1, Part A (2024)

Background: Psoriatic arthritis (PsA) is classified as a form of chronic inflammatory arthritis that is linked to psoriatic skin disease. Atherosclerosis is primarily triggered and exacerbated by the initial inflammatory response. Understanding the risk factors for endothelial dysfunction in PsA may help develop interventions for the prompt identification and better management of high-risk patients. Endothelial dysfunction is the first step toward cardiovascular disease. Assessing the probability of erectile dysfunction in psoriatic arthritis patients was the main goal of this study.
Methods: Sixty PsA patients who satisfied the CASPAR classification criteria for PsA and forty control subjects who underwent a thorough medical history, physical examination, and full lipid profile testing were the subjects of a case-control study. Using the DAPSA score, disease activity is assessed. All patients and controls had their brachial artery flow-mediated dilatation evaluated.
Results: There was no discernible difference between the two groups based on demographic data. PsA patients were 33.4±6.03 years old on average. The mean body mass index was 27.02±1.7 kg/m2. When comparing PsA patients to healthy controls, the levels of LDL, CHOL, and TG were statistically significantly higher (p-value < 0.001). With p-values of 0.015 and 0.005, respectively, patients with PsA showed statistically significant decreases in brachial artery FMD and increases in the percentage of ED when compared to controls.
Conclusion: The study conclude to that psoriatic arthritis has a correlation with a heightened risk of endothelial dysfunction. The situation is also further complicated by the body's abnormal lipid metabolism processes.