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International Journal of Orthopaedics and Rheumatology

Vol. 6, Issue 1, Part A (2024)

Impact of tobacco smoking on response to tumor necrosis factor-alpha inhibitor treatment in a sample of Iraqi patients with ankylosing spondylitis

Author(s):

Ali Falah Zbala and Mohammed Hadi Alosami

Abstract:

Background: Tobacco smoking has a great burden on human health status and is the cause of many morbidities and a high death rate. Smoking is involved in the etiology and deterioration of ankylosing spondylitis. 
Aim of the study: To assess the effect of smoking in affecting response to tumor necrosis factor-alpha inhibitor treatment in ankylosing spondylitis patients.
Patients and Methods: A retrospective cross-sectional study was conducted at the Rheumatology Unit of Baghdad Teaching Hospital/Medical Complex in Baghdad City-Iraq for a duration of six months from 1st December 2021 to 31st May 2022 on a sample of 150 Iraqi patients with ankylosing spondylitis. Ankylosing spondylitis patients has been diagnosed based on the modified New York criteria and tumor necrosis factor-alpha inhibitor prescribed for them. The smoking status, ESR, BASDAI, and BASFI of patients were assessed by the researcher. 
Results: Non-smoking was observed in 46.7% of ankylosing spondylitis patients, while current smoking was observed in 46.7% of patients and ex-smoking in 6.6% of them. The mean ESR level after 6 months of treatment was significantly higher among ankylosing spondylitis patients with current smoking (P=0.002). The mean BASDAI score after 6 months of treatment was significantly higher among ankylosing spondylitis patients with ex-smoking (p<0.001). Similarly, the mean BASFI score after 6 months of treatment was significantly higher among ankylosing spondylitis patients with ex-smoking (P=0.004). 
Conclusions: Smoking has adverse effects on patients with ankylosing spondylitis treated by tumor necrosis factor inhibitors with poorly controlled disease activity and inadequate treatment response.
 

Pages: 42-47  |  286 Views  140 Downloads


International Journal of Orthopaedics and Rheumatology
How to cite this article:
Ali Falah Zbala and Mohammed Hadi Alosami. Impact of tobacco smoking on response to tumor necrosis factor-alpha inhibitor treatment in a sample of Iraqi patients with ankylosing spondylitis. Int. J. Orthop. Rheumatol. 2024;6(1):42-47. DOI: 10.33545/26649691.2024.v6.i1a.18