Vol. 6, Issue 1, Part A (2024)

Behçet’s Disease (BD) is a rare, chronic, multi-system vasculitis with a complex and variable clinical presentation, making early diagnosis difficult. We report a case of a 49-year-old female of Middle Eastern descent with a history of recurrent oral ulcers, arthralgias, and erythema nodosum, ultimately diagnosed with BD after years of misdiagnosis. The patient’s response to biologic therapy, specifically Etanercept, highlights the importance of individualized treatment. This case report addresses the diagnostic challenges of BD and emphasizes the importance of early recognition and a multidisciplinary approach to treatment.